Key result
Sickle cell disease linked to increased LV mass and ~40% pulmonary hypertension prevalence.
Why the study?
Sickle cell disease may adversely affect cardiac function, but evaluation of left ventricular systolic and diastolic functions in Saudi patients with SCD was needed.
Are left ventricular systolic and diastolic functions altered in Saudi patients with sickle cell disease compared to matched controls?
Case-Control (n=90)
Are left ventricular systolic and diastolic functions altered in Saudi patients with sickle cell disease compared to matched controls?
Saudi patients with the Arab-Indian haplotype of sickle cell disease frequently develop LV diastolic dysfunction and pulmonary hypertension despite preserved ejection fraction.
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May warrant cardiac screening in Saudi SCD; leaves open prognostic value and intervention thresholds.
Mohammed Fakhry Abdul-Mohsen (2012) conducted a case-control in Sickle cell disease (n=90). Sickle cell disease vs. Age- and sex-matched controls was evaluated on Left ventricular systolic and diastolic functions. Sickle cell disease in Saudi patients was associated with increased left ventricular dimensions and mass index, with LV diastolic dysfunction present in 24% and pulmonary hypertension in 40%.
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