Why the study?
Does chronic transfusion status affect cardiac dimensions and load-independent measures of function in children with sickle cell anemia?
Population
77 patients with sickle cell anemia (SCA), ages 2 to 22 years (mean 11.7 +/- 4.7 years)
Comparison
Chronic transfusion protocol (n=20) vs Non-transfused (n=57)
Design
Cross-sectional
Authors
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May link chronic transfusion to diastolic dysfunction markers in pediatric sickle cell anemia; hypothesis-generating and requires prospective validation.
Does chronic transfusion status affect cardiac dimensions and load-independent measures of function in children with sickle cell anemia?
Children with sickle cell anemia exhibit volume-overloaded hearts with preserved systolic function, but those on chronic transfusion protocols may develop diastolic dysfunction despite iron chelation.
Batra et al. (2002) studied this question.
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