Late onset adrenomyeloneuropathy.

Increased Beta2-microglobulin in CSF of multiple sclerosis Sir: Increased cerebrospinal fluid (CSF) levels of beta2-microglobulin (B2m) have been found in a number of primary central nervous system (CNS) diseases' as well as in neurological complications of systemic malignancies,23 cerebrovascular lesions4 and CNS infection.5 However, there are dis- crepancies in the values obtained by several authors for B2m in CSF of multiple sclerosis patients. 1 2 5 This may be due to the fact that these studies were performed in small series of patients without taking into account whether they were in relapse or not. We felt, therefore, that the study of CSF B2m in relation to clinical activity in multiple sclero- sis would be of interest.