April 20, 2017Physical Review Letters

Mechanism for Amplitude Alternans in Electrocardiograms and the Initiation of Spatiotemporal Chaos

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Population

Rabbit hearts and a simplified ionic cell model

Design

Preclinical

Authors

DCDiandian Diana Chen RGRichard A. GrayCenter for Devices and Radiological Health IUIlija UzelacGeorgia Institute of Technology

Discussion

Member takes

Implication

This preclinical study identifies sodium current inactivation as a key driver of action potential amplitude alternans and subsequent arrhythmogenic spatiotemporal chaos.

Structured PICO

Population

Rabbit hearts and a simplified ionic cell model

Intervention

Experimental conditions to minimize action potential (AP) duration dynamics and 2D simulations

Outcome

Mechanism for action potential amplitude alternans and spiral breakup

This preclinical study identifies sodium current inactivation as a key driver of action potential amplitude alternans and subsequent arrhythmogenic spatiotemporal chaos.

Cite This Study

Chen et al. (2017) studied this question.

synapsesocial.com/papers/6a87c2e09842aaac2ffb0bc5 https://doi.org/10.1103/physrevlett.118.168101

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Implication

This preclinical study identifies sodium current inactivation as a key driver of action potential amplitude alternans and subsequent arrhythmogenic spatiotemporal chaos.