Why the study?
Does cilnidipine affect L- and T-type calcium currents and sinoatrial node action potential in guinea pig and rabbit models?
Population
Guinea pig ventricular myocytes and rabbit sinoatrial node tissue
Design
Preclinical
Authors
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May underlie negative chronotropic effects in animal models; leaves open translation to human electrophysiology.
Does cilnidipine affect L- and T-type calcium currents and sinoatrial node action potential in guinea pig and rabbit models?
Cilnidipine exhibits inhibitory effects on T-type calcium currents, which may explain its negative chronotropic properties.
Takeda et al. (2004) studied this question.
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