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Does enalapril in combination with cilnidipine reduce microalbuminuria more than enalapril alone in patients with type-2 diabetes mellitus and hypertension?
Does enalapril in combination with cilnidipine reduce microalbuminuria more than enalapril alone in patients with type-2 diabetes mellitus and hypertension?
The addition of cilnidipine to enalapril provides an additive effect in reducing microalbuminuria in patients with type-2 diabetes and hypertension.
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Supports adding cilnidipine to enalapril for greater microalbuminuria reduction in T2DM hypertension; extends ACEI combination evidence.
The aim of our study was to find out the antiproteinuric effect of enalapril angiotensin-converting enzyme (ACE inhibitor) alone or in combination with cilnidipine in patients with type-2 diabetes mellitus. The study was conducted on 71 patients with type-2 diabetes mellitus patients with hypertension and microalbuminuria. They were divided into two groups randomly as follows: Group I (enalaprilalone, n = 36) and Group II (enalapril with cilnidipine, n = 35). In both the groups, baseline 24 h urinary albumin was estimated and was repeated every 3 months upto 1-year. After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II. In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001). We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.
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Singh et al. (2015) studied this question.
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