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Do alterations in preload and afterload affect indices of myocardial function in anaesthetized open-chest dogs?
Do alterations in preload and afterload affect indices of myocardial function in anaesthetized open-chest dogs?
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In an open-chest dog model, maximum acceleration, peak flow, and maximum dP/dt are load-dependent, whereas (Max dP/dt)/IP is load-independent.
The effect of load changes on various indices of myocardial function was investigated in anaesthetized open-chest dogs. Alterations of left ventricular end diastolic volume were associated with changes of maximum acceleration, peak flow, and maximum dP/dt, as were sudden changes in afterload (aortic impedance). (Max dP/dt)/IP was not affected by these manoeuvres.
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Chung et al. (1974) studied this question.
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