Salidroside Modulates Insulin Signaling in a Rat Model of Nonalcoholic Steatohepatitis

A growing body of evidence has shown the beneficial effects of salidroside in cardiovascular and metabolic diseases. This study aimed to evaluate the therapeutic effects of salidroside on nonalcoholic steatohepatitis (NASH) in rats and explore the underlying mechanisms related to insulin signaling. A rat model of NASH was developed by high‐fat diet for 14 weeks. From week 9 onward, the treatment group received oral salidroside (4.33 mg/kg) daily for 6 weeks. Salidroside effectively attenuated steatosis and vacuolation of hepatic tissue, with a dramatic decrease in liver triglycerides and free fatty acid levels ( P < 0.01). Dysregulation of FINS, FBG, HOMA‐IR, ALT, and AST in serum was ameliorated with salidroside treatment ( P < 0.01). In the liver, salidroside induced significant increases in key molecules in the insulin signaling pathway, such as phosphorylated insulin receptor substrate 1 (IRS1), phosphoinositide 3‐kinase (PI3K), and protein kinase B (PKB), with a significant decrease in SREBP‐1c levels ( P < 0.01). Therefore, salidroside effectively protected rats from high‐fat‐diet‐induced NASH, which may be partially attributed to its effects on the hepatic insulin signaling pathway.