Key result
Salidroside at 50 mg/kg/day significantly improved glucose and insulin tolerance in high-fat diet-induced obese mice by repressing white adipose tissue inflammation and improving leptin sensitivity.
Why the study?
Does salidroside improve glucose homeostasis in high-fat diet-induced obese mice?
Does salidroside improve glucose homeostasis in high-fat diet-induced obese mice?
Salidroside improves glucose homeostasis and reduces adipose tissue inflammation in high-fat diet-induced obese mice, suggesting potential as an anti-diabetic agent.
May support preclinical exploration of salidroside in metabolic models; leaves open human translation.
Salidroside is a functionally versatile natural compound from the perennial flowering plant Rhodiola rosea L. Here, we examined obese mice treated with salidroside at the dosage of 50 mg/kg/day for 48 days. Mice treated with salidroside showed slightly decreased food intake, body weight and hepatic triglyceride content. Importantly, salidroside treatment significantly improved glucose and insulin tolerance. It also increased insulin singling in both liver and epididymal white adipose tissue (eWAT). In addition, salidroside markedly ameliorated hyperglycemia in treated mice, which is likely due to the suppression of gluconeogenesis by salidroside as the protein levels of a gluconeogenic enzyme G6Pase and a co-activator PGC-1α were all markedly decreased. Further analysis revealed that adipogenesis in eWAT was significantly decreased in salidroside treated mice. The infiltration of macrophages in eWAT and the productions of pro-inflammatory cytokines were also markedly suppressed by salidroside. Furthermore, the leptin signal transduction in hypothalamus was improved by salidroside. Taken together, these euglycemic effects of salidroside may due to repression of adipogenesis and inflammation in eWAT and stimulation of leptin signal transduction in hypothalamus. Thus, salidroside might be used as an effective anti-diabetic agent.
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Wang et al. (2016) studied Obesity and insulin resistance. Salidroside vs. Vehicle (distilled water) was evaluated on Glucose and insulin tolerance. Salidroside at 50 mg/kg/day significantly improved glucose and insulin tolerance in high-fat diet-induced obese mice by repressing white adipose tissue inflammation and improving leptin sensitivity.
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