Prostacyclin (Pgi2) Inhibits the Formation of Platelet Thrombi in Arterioles and Venules of the Hamster Cheek Pouch
Why the study?
Does prostacyclin inhibit ADP-induced platelet thrombi formation in the microcirculation of the hamster cheek pouch?
Population
Hamster cheek pouch microcirculation, isolated hamster aorta, and hamster platelets
Comparison
Prostacyclin applied locally vs Prostaglandin E1 and control conditions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports potent antithrombotic effects in animal microcirculation; leaves open translation to human thrombosis prevention.
Structured PICO
Does prostacyclin inhibit ADP-induced platelet thrombi formation in the microcirculation of the hamster cheek pouch?
P
Population
Hamster cheek pouch microcirculation (venules 30-40 micron diameter and arterioles 40-80 micron diameter), isolated hamster aorta, and hamster platelets
I
Intervention
Prostacyclin (PGI2) applied locally (up to 500 ng/ml in Krebs solution)
C
Comparator
Prostaglandin E1 (for potency comparison) and control conditions
O
Outcome
Time required to induce platelet thrombi formation and embolization in venules, and total time of thrombi observation in arterioles following damagesurrogate
Prostacyclin is a highly potent inhibitor of platelet thrombus formation in the microcirculation, significantly more potent than prostaglandin E1.
Cite This Study
Higgs et al. (1978) studied this question.