What question did this study set out to answer?

To determine how changes in hindlimb metabolic rate affect local arterial hypoxia-induced hyperemia and steady-state blood flow autoregulation.

November 1, 1978Circulation ResearchOpen Access

Effect of changing metabolic rate on local blood flow control in the canine hindlimb.

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Why the study?

Does changing metabolic rate affect local blood flow control in the canine hindlimb?

Population

Anesthetized dogs (canine hindlimb model)

Comparison

Changing metabolic rate via direct electrical… vs Resting metabolic rate

Design

Preclinical

Authors

AGA. H. GoodmanThe University of Sydney RERosemarie EinsteinThe University of Sydney HGHarris J. GrangerUniversity of Siena

Discussion

Member takes

Implication

Metabolic rate may sharpen skeletal muscle autoregulation; leaves open translation to human physiology or disease.

Key Points

To determine how changes in hindlimb metabolic rate affect local arterial hypoxia-induced hyperemia and steady-state blood flow autoregulation.
Measured hindlimb blood flow in anesthetized dogs subjected to 6-minute bouts of graded arterial hypoxia and pressure-induced changes.
Increased metabolic rate using direct electrical muscle stimulation (0.5 to 1.5 pulses/second) and decreased it in three dogs using localized cooling.
Arterial hypoxia progressively elevated hindlimb blood flow across all stimulation rates, with responses to severe hypoxia (arterial oxygen saturation < 50%) significantly enhanced during muscle stimulation compared to rest.
Steady-state blood flow autoregulation was weak at baseline, improved markedly with increasing muscle stimulation, and was depressed by cooling, showing a close correlation with hindlimb metabolic rate.

Structured PICO

Does changing metabolic rate affect local blood flow control in the canine hindlimb?

Population

Anesthetized dogs (canine hindlimb model)

Intervention

Changing metabolic rate via direct electrical stimulation of hindlimb muscles (0.5 to 1.5 pulses/second) or cooling, combined with graded arterial hypoxia or blood pressure changes

Comparator

Resting metabolic rate

Outcome

Hindlimb blood flow control (hyperemic response to hypoxia and steady state autoregulation to blood pressure changes)surrogate

Tissue metabolic rate determines the precision of local blood flow control in the canine hindlimb, with higher metabolic rates enhancing autoregulation.

Cite This Study

Goodman et al. (1978) studied this question.

synapsesocial.com/papers/6a87c52ee6314279fbfb0b8c https://doi.org/10.1161/01.res.43.5.769

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Effect of changing metabolic rate on local blood flow control in the canine hindlimb.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of changing metabolic rate on local blood flow control in the canine hindlimb.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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