January 1, 1988Canadian Journal of Physiology and Pharmacology
Regulation of canine skeletal muscle and hindlimb blood flow in acute anemia
Key result
Sympathetic stimulation blunts skeletal muscle blood flow less during acute anemia than normal hematocrit.
- P<0.05
- n=16
Why the study?
The effects of sympathetic nerve stimulation on skeletal muscle and hindlimb blood flow during acute anemia were not fully understood.
Comparison
Sympathetic nerve stimulation during normal hematocrit vs during anemia (Hct = 14%)
Design
Preclinical experimental study with nerve stimulation and blood flow measurements
Authors
Discussion
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Implication
Attenuated sympathetic vasoconstriction during anemia may preserve perfusion; hypothesis-generating for autonomic responses and requires human confirmation.
Structured PICO
P
Population
16 anesthetized, paralyzed, and ventilated dogs divided into skeletal muscle and hindlimb groups to study blood flow during anemia.
I
Intervention
Sympathetic nerve stimulation (distal end of transected left sciatic nerve) for 4-min intervals during acute anemia (Hct = 14%)
C
Comparator
Sympathetic nerve stimulation at normal hematocrit
O
Outcome
Arterial blood pressure, hindlimb or muscle blood flow, vascular resistance, and vascular hindrancesurrogate
Main Result
p-value: p=<0.05
In a canine model, acute anemia blunts the maximal sympathetic vasoconstrictor response in skeletal muscle and hindlimb blood flow compared to normal hematocrit.
Cite This Study
Kubes et al. (1988) studied Anemia (n=16). Sympathetic nerve stimulation vs. Normal hematocrit was evaluated on Blood flow, vascular resistance, and vascular hindrance (p=<0.05). Maximal sympathetic stimulation produced a significant decrease in skeletal muscle and hindlimb blood flow during anemia, though the reduction was less than at normal hematocrit (p<0.05).