Population
Single left ventricular myocytes isolated from 8-month-old and 19-month-old genetically diabetic rats and…
Comparison
Beta-adrenergic stimulation and other… vs Age-matched control cells
Design
Preclinical
Authors
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May impair inotropic reserve in diabetic hearts; leaves open translational relevance to human cardiomyopathy.
Genetically diabetic rats exhibit a blunted L-type calcium current response to beta-adrenergic stimulation despite normal basal calcium current properties.
Tsuchida et al. (1994) studied this question.
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