Single‐Crystal to Single‐Crystal Cross‐Linking of an Interpenetrating Chiral Metal–Organic Framework and Implications in Asymmetric Catalysis

Support framework: Post-synthesis modification of an interpenetrating Zn-based chiral metal–organic framework with Ti(OiPr)4 results in a Lewis acidic catalyst (see picture; gray C, white H, red O, green Ti) with modest enantioselectivity in the asymmetric addition of diethylzinc to aldehydes. The Ti(OiPr)4-treated framework contains single-crystal to single-crystal cross-linking of the two interpenetrating networks.