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March 1, 1973Circulation ResearchOpen Access

Stimulation of Aldosterone Secretion by Hemorrhage in Dogs after Nephrectomy and Decapitation

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Population

8 intact, anesthetized dogs

Comparison

Nephrectomy and decapitation followed by… vs Control state

Design

Preclinical

Follow-up

11 hours (8 hours post-surgery plus 3 hours post-hemorrhage)

Authors

RMRobert E. McCaaNewYork–Presbyterian HospitalCMCONNIE S. McCAAUniversity of Mississippi Medical CenterACAllen W. CowleyMedical College of Wisconsin

Discussion

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Overview

Hypothesis-generating for potassium-mediated aldosterone control independent of RAS/ACTH; leaves open translation to human cardiovascular disease.

Structured PICO

P
Population
8 intact, anesthetized dogs
I
Intervention
Nephrectomy and decapitation followed by hemorrhage (lowering arterial blood pressure to 70 mm Hg at 8 hours post-surgery), with or without hemodialysis to prevent serum potassium rise
C
Comparator
Control state (baseline before surgery and hemorrhage)
O
Outcome
Aldosterone secretory ratesurrogate

Normal levels of aldosterone secretion can be maintained and stimulated by hemorrhage in the absence of the renin-angiotensin system and ACTH, provided serum potassium rises.

Cite This Study

McCaa et al. (1973) studied this question.

synapsesocial.com/papers/6a87c8005a7984ab7cfb05cahttps://doi.org/10.1161/01.res.32.3.356
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE DISSOCIATION OF ALDOSTERONE SECRETION AND SYSTEMIC RENIN AND ANGIOTENSIN II LEVELS DURING THE CORRECTION OF SODIUM DEFICIENCY1971 · 56 citations
  2. 2Increased Plasma Aldosterone Concentration In Response to Hemodialysis In Nephrectomized Man1972 · 65 citations
  3. 3Production of Aldosterone by Rat Adrenal Glands in vitro.1956 · 41 citations