Why the study?
Does bilateral nephrectomy or a low sodium diet alter the increase in plasma renin levels produced by hemorrhage in dogs?
Population
Pentobarbital-anesthetized normal dogs
Comparison
Bilateral nephrectomy or low sodium diet for 14… vs Normal dogs fed a diet providing approximately…
Design
Preclinical
Follow-up
up to 60 minutes post-hemorrhage
Authors
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Should not change clinical hemorrhage management; leaves open translational validation of renal renin dependence in hypovolemia.
Does bilateral nephrectomy or a low sodium diet alter the increase in plasma renin levels produced by hemorrhage in dogs?
The kidneys are essential for the hemorrhage-induced increase in plasma renin, and a low sodium diet amplifies this renin response.
Otsuka et al. (1968) studied this question.
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