The Comparison of Propofol and Ketofol Side Effects During Sedation with Spinal Anesthesia

Aim: Research into ideal sedative agents for patient comfort, cardiopulmonary stability and fast recovery without mental impairments continues.Our primary objectives were to compare haemodynamic parameters, recovery time, emergence reactions, vomiting and satisfaction ratios between groups administered propofol-ketamine or propofol.Material and Method: Sixty-one ASA I-III adult patients undergoing elective orthopaedic lower limb surgery under spinal anaesthesia were studied.The Mini-mental State examination was used preoperatively and post-operatively.Vital signs were recorded preoperatively, during surgery and during recovery.After sensory block was obtained, patients received a 0.4 mg kg -1 propofol loading dose.Pre-surgery, continuous infusions started: Group P, propofol with saline; Group KP, propofol with ketamine in a 3:1 ratio.Postsurgery, in the post-anaesthesia care unit, patients' vital signs were monitored, and side-effects and satisfaction ratios recorded.Results: The groups did not differ in demographic variables.There was no statistically significant difference in preoperative and postoperative MMT examination scores, systolic blood pressure, mean blood pressure, heart rate, respiratory rate or oxygen saturation between groups (p>0.05).But in group P four patients had deep hypotension and two of them need sedation termination.Mean recovery time of Group KP and Group P was 14 min and 7 min, respectively.No respiratory adverse event was observed.In Group KP, four patients vomited.There were no psychomimetic adverse reactions.Conclusion: It was found that ketamine infusion (ratio 3:1) prolonged recovery time but it is far less important near its haemodynamic benefits.In this combination, propofol may counterbalance psychomimetic effects of ketamine, but not vomiting.