Population
Primary cardiomyocyte cultures from neonatal rats
Design
Preclinical
Follow-up
3-5 days
Authors
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Uniform CVB toxicity in cardiomyocytes extends in vitro models; leaves open human myocarditis relevance and serotype-independent therapies.
All six Coxsackievirus B serotypes induce irreversible cytopathic effects in primary cardiomyocytes, indicating that serotype variation does not limit susceptibility to infection.
Ahn et al. (2004) studied this question.
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