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June 10, 2019Journal of Virology

Extracellular Albumin and Endosomal Ions Prime Enterovirus Particles for Uncoating That Can Be Prevented by Fatty Acid Saturation

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Why the study?

There is limited information about the uncoating of enteroviruses under physiological conditions.

Population

Echovirus 1 and other B-group enteroviruses

Comparison

Extracellular albumin and endosomal ionic changes

Design

Biochemical and structural study

Authors

VRVisa RuokolainenUniversity of JyväskyläADAušra DomanskaUniversity of HelsinkiMLMira LaajalaUniversity of Jyväskylä

Discussion

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Overview

Extracellular albumin primes B-group enteroviruses to a metastable infectious state; leaves open its role in physiological uncoating and entry.

Structured PICO

P
Population
echovirus 1 and other B-group enteroviruses
I
Intervention
extracellular albumin and endosomal ions
O
Outcome
viral uncoating and genome release

Extracellular albumin and endosomal ions play a key role in priming and promoting the uncoating of B-group enteroviruses.

Cite This Study

Ruokolainen et al. (2019) studied this question.

synapsesocial.com/papers/6a87cd740112b7b407bb50cdhttps://doi.org/10.1128/jvi.00599-19
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alteration of capsid proteins of coxsackievirus A13 by low ionic concentrations1975 · 34 citations
  2. 2Coxsackievirus A9 Infects Cells via Nonacidic Multivesicular Bodies2014 · 34 citations
  3. 3The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs2016 · 55 citations
  4. 4Influence of different ionic and pH environments on structural alterations of poliovirus and their possible relation to virus uncoating1991 · 52 citations
  5. 5The poliovirus 135S particle is infectious1996 · 136 citations