Why the study?
How enterovirus particles or RNA genomes cross the endosome membrane into the host cell cytoplasm remains unknown.
Population
Cells infected with rhinovirus 2, echovirus 18, echovirus 30, or enterovirus 71, and uninfected cells
Comparison
Inhibition with bafilomycin A1 or wiskostatin vs untreated cells
Design
Cryo-electron tomography study
Authors
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Hypothesis-generating for enterovirus entry; leaves open mechanisms for non-enveloped virus infection.
Enteroviruses enter the host cell cytoplasm via cell-mediated endosome disruption, a mechanism that may be common across many enteroviruses.
Ishemgulova et al. (2023) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: