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November 7, 2024Communications BiologyOpen Access

Endosome rupture enables enteroviruses from the family Picornaviridae to infect cells

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Why the study?

How enterovirus particles or RNA genomes cross the endosome membrane into the cytoplasm remains unknown.

Population

Infected cells

Comparison

Bafilomycin A1 or wiskostatin treatment vs control cells

Design

Cryo-electron tomography study

Authors

AIAygul IshemgulovaUniversity of OstravaLML MukhamedovaCentral European Institute of TechnologyZTZ TrebichalskáCentral European Institute of Technology – Masaryk University

Discussion

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Overview

Endosomal rupture enables enterovirus entry; extends mechanistic virology but leaves open antiviral strategies for myocarditis.

Structured PICO

P
Population
Cells infected with enteroviruses (in vitro model)
I
Intervention
Bafilomycin A1 (blocks endosome acidification) or wiskostatin (inhibits post-endocytic membrane remodeling)
C
Comparator
Control cells
O
Outcome
Mechanism of enterovirus entry into the cytoplasm (endosome rupture)

Enteroviruses enter the host cell cytoplasm by inducing endosome rupture, a mechanism likely shared across the Picornaviridae family.

Cite This Study

Ishemgulova et al. (2024) studied this question.

synapsesocial.com/papers/6a718881f44fa9f079df503fhttps://doi.org/10.1038/s42003-024-07147-9
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