Why the study?
It is unknown how enterovirus virions assemble around newly synthesized genomes on remodeled membranes and how they are loaded into autophagic membranes for release through secretory autophagy.
This study provides an integrated structural framework for multiple stages of the poliovirus life cycle, identifying key host-cell autophagy factors involved in virion assembly and release.
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Direct membrane assembly in poliovirus may inform antiviral targeting; leaves open extension to other enteroviruses and secretory autophagy mechanisms.
Dahmane et al. (2022) studied this question.
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