October 11, 2005AutophagyOpen Access

Topology of Double-Membraned Vesicles and the Opportunity for Non-Lytic Release of Cytoplasm

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Population

Mammalian cells infected with positive-strand RNA viruses (e.g., poliovirus)

Design

Preclinical

Authors

Discussion

Supports autophagosome-mediated non-lytic poliovirus release; hypothesis-generating for cytoplasmic virus mechanisms in animal models.

Population

Mammalian cells infected with positive-strand RNA viruses (e.g., poliovirus)

Intervention

RNAi treatment to reduce LC3 or Atg12p concentrations

Outcome

Yields of extracellular and intracellular virus

Autophagosome-like double-membranes may provide a mechanism for the non-lytic release of cytoplasmic viruses such as poliovirus.

Kirkegaard et al. (2005) studied this question.

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