Key result
The poliovirus 3AB protein alone is sufficient to induce the formation of double-membraned liposomes via the invagination of single-membraned liposomes and intracellular membranes.
Population
HeLa cells and purified liposomes
Design
Preclinical
Authors
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Remains preclinical with no clinical implications; leaves open relevance to poliovirus pathogenesis or cellular autophagy in vivo.
A single poliovirus protein, 3AB, is sufficient to induce membrane remodeling similar to autophagosome formation, providing a model for understanding viral and cellular membrane dynamics.
Wang et al. (2013) studied Poliovirus infection / membrane remodeling. Poliovirus 3AB protein was evaluated on Formation of double-membraned liposomes. The poliovirus 3AB protein alone is sufficient to induce the formation of double-membraned liposomes via the invagination of single-membraned liposomes and intracellular membranes.
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