Why the study?
The study was conducted to assess the role of poliovirus capsid proteins in autophagy development during infection.
Poliovirus capsid proteins interact with the cellular autophagy pathway, suggesting autophagy acts as an antiviral response that targets capsid proteins for sequestration.
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Indicates autophagy may restrict poliovirus in animal models; leaves open relevance to human infection or therapy.
Zimina et al. (2021) studied this question.
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