October 11, 2006Journal of Biological ChemistryOpen Access

Evidence for the Formation of a Heptameric Ion Channel Complex by the Hepatitis C Virus P7 Protein in Vitro

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Population

In vitro model

Design

Preclinical

Authors

DCDean ClarkeUniversity of Leeds SGStephen GriffinUniversity of Leeds LBLucy BealesMologic (United Kingdom)

Discussion

Member takes

Implication

Establishes a liposome model for HCV p7 channel structure; leaves open clinical targeting of amantadine-sensitive p7 in patients.

Structured PICO

Population

In vitro model (bacterial expression system for p7 based on glutathione S-transferase fusion methodology, liposomes, suspended lipid bilayers)

Intervention

p7 protein expression and structural analysis

Outcome

Stoichiometry and structure of p7 ion channel complexessurrogate

The study provides evidence for a heptameric stoichiometry of the hepatitis C virus p7 ion channel complex in vitro, validating a system for future high-resolution structural analysis and drug design.

Cite This Study

Clarke et al. (2006) studied this question.

synapsesocial.com/papers/6a87cd7618bab47e1b0618e5 https://doi.org/10.1074/jbc.m602434200

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Evidence for the Formation of a Heptameric Ion Channel Complex by the Hepatitis C Virus P7 Protein in Vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for the Formation of a Heptameric Ion Channel Complex by the Hepatitis C Virus P7 Protein in Vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider