Population
Escherichia coli cells (BL21 (DE3) pLysS and BL21 (DE3) cells)
Design
Preclinical
Authors
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Bacterial lysis by 2B/3A does not inform antiviral therapy; leaves open roles in eukaryotic membrane disruption.
Poliovirus nonstructural proteins 2B and 3A contain hydrophobic domains and act as membrane-active peptides that alter bacterial membrane permeability and induce lysis.
Lama et al. (1992) studied this question.
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