Population
Human and rodent neural tissue (central nervous system homogenates, synaptosomes)
Design
Preclinical
Authors
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May guide research on poliovirus neurotropism; leaves open clinical relevance of synaptic enrichment in humans.
Poliovirus binding sites are widely distributed in the human central nervous system and enriched in synaptosomes, suggesting synaptic endings may play a role in the virus's motor tropism.
Brown et al. (1987) studied this question.
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