Key result
Type I interferon response, along with the poliovirus receptor and host factors for translation initiation, is an important determinant of poliovirus tissue tropism by inhibiting viral replication in non-target tissues.
Type I interferon response is a critical determinant of poliovirus tissue tropism, restricting viral replication in non-neural tissues.
May inform poliovirus tropism models; leaves open therapeutic translation pending prospective validation.
Poliovirus is the causative agent of an acute disease of the central nervous system, poliomyelitis. Poliovirus will be eradicated in the near future by a world-wide vaccination program. Poliovirus is a neurotropic virus that produces severe lesions selectively in the CNS. However, a basic question why poliovirus exhibits neurotropic property has not been elucidated. Poliovirus receptor and host factors involved in the translation initiation of viral protein, which are required for virus replication, play important roles in determining tissue tropism. We found that type I interferon response is also an important determinant of poliovirus tissue tropism. Type I interferon inhibits viral replication in the non-target tissues. The tissue tropism of poliovirus may be determined based on the balance of these mechanisms.
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Satoshi Koike (2004) conducted a review in Poliovirus infection. Poliovirus infection mechanisms (PVR, IRES, Type I Interferon) was evaluated. Type I interferon response, along with the poliovirus receptor and host factors for translation initiation, is an important determinant of poliovirus tissue tropism by inhibiting viral replication in non-target tissues.
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