November 1, 2008Chemistry & Biodiversity

Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1‐Substituted‐2‐[(Benzotriazol‐1/2‐yl)methyl]benzimidazoles

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Population

Cell-based assays for various viruses including Yellow Fever Virus, Bovine Viral Diarrhoea Virus, HIV-1…

Design

Preclinical

Authors

MTMichele TonelliFondazione Bruno Kessler GPGiuseppe PagliettiUniversity of Sassari VBVito BoidoUniversity of Genoa

Discussion

Member takes

Implication

Warrants further preclinical testing for RSV; leaves open any clinical role.

Structured PICO

Population

Cell-based assays for various viruses including Yellow Fever Virus (YFV), Bovine Viral Diarrhoea Virus (BVDV), HIV-1, Coxsackie Virus type B2 (CVB2), Poliovirus type-1 (Sb-1), Respiratory Syncytial Virus (RSV), Vesicular Stomatitis Virus (VSV), Reo-1, Herpes Simplex type 1 (HSV-1), and Vaccinia Virus (VV)

Intervention

Forty-three 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles bearing either linear (dialkylamino)alkyl- or bulkier (quinolizidin-1-yl)alkyl moieties at position 1

Outcome

Cytotoxicity and antiviral activity (EC50)surrogate

Benzimidazole derivatives demonstrate potent antiviral activity against Respiratory Syncytial Virus (RSV) in cell-based assays.

Cite This Study

Tonelli et al. (2008) studied this question.

synapsesocial.com/papers/6a87cf29533d786da9062145 https://doi.org/10.1002/cbdv.200890203

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Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1‐Substituted‐2‐[(Benzotriazol‐1/2‐yl)methyl]benzimidazoles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1‐Substituted‐2‐[(Benzotriazol‐1/2‐yl)methyl]benzimidazoles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider