April 1, 1961The Journal of Experimental MedicineOpen Access

Relationship Between Structure of Benzimidazole Derivatives and Selective Virus Inhibitory Activity

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Population

In vitro models infected with influenza B and polio type 2 viruses

Comparison

Benzimidazole, benzotriazole, and… vs Benzimidazole and untreated controls

Design

Preclinical

Authors

ITIgor TammRockefeller Foundation RBRostom BablanianState University of New York MNM. M. NemesUnited States Military Academy

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether HBB derivatives merit in vivo antiviral development.

Structured PICO

Population

In vitro models (chorioallantoic membrane and monkey kidney cells) infected with influenza B and polio type 2 viruses

Intervention

Benzimidazole, benzotriazole, and naphthimidazole derivatives (65 compounds, including 2-(alpha-hydroxybenzyl)-benzimidazole [HBB])

Comparator

Benzimidazole (reference compound) and untreated controls

Outcome

Virus inhibitory activity (inhibition of virus multiplication and cytopathic effects)surrogate

HBB and its derivatives demonstrate selective antiviral activity against poliovirus type 2 in vitro without significant cellular toxicity.

Cite This Study

Tamm et al. (1961) studied this question.

synapsesocial.com/papers/6a91207a17bbbfe73e745dd4 https://doi.org/10.1084/jem.113.4.625

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April 1, 1961The Journal of Experimental MedicineOpen Access

Relationship Between Structure of Benzimidazole Derivatives and Selective Virus Inhibitory Activity

View Full Paper

Ask AI

Bookmark

Population

In vitro models infected with influenza B and polio type 2 viruses

Comparison

Benzimidazole, benzotriazole, and… vs Benzimidazole and untreated controls

Design

Preclinical

Authors

ITIgor TammRockefeller Foundation RBRostom BablanianState University of New York MNM. M. NemesUnited States Military Academy

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether HBB derivatives merit in vivo antiviral development.

Structured PICO

Population

In vitro models (chorioallantoic membrane and monkey kidney cells) infected with influenza B and polio type 2 viruses

Intervention

Benzimidazole, benzotriazole, and naphthimidazole derivatives (65 compounds, including 2-(alpha-hydroxybenzyl)-benzimidazole [HBB])

Comparator

Benzimidazole (reference compound) and untreated controls

Outcome

Virus inhibitory activity (inhibition of virus multiplication and cytopathic effects)surrogate

HBB and its derivatives demonstrate selective antiviral activity against poliovirus type 2 in vitro without significant cellular toxicity.

Cite This Study

Tamm et al. (1961) studied this question.

synapsesocial.com/papers/6a91207a17bbbfe73e745dd4 https://doi.org/10.1084/jem.113.4.625

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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