November 1, 1968Experimental Biology and Medicine

The Spectrum of Rhinovirus Inhibition by 2-( -Hydroxybenzyl)-benzimidazole and D-(-) -2- ( -Hydroxybenzyl)-benzimidazole HC1

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Population

Rhinovirus strains representative of the 55 numbered serotypes and one subtype tested in HeLa and WI-38 cell…

Design

Preclinical

Authors

JGJack M. GwaltneyRutgers, The State University of New Jersey

Discussion

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Implication

Variable rhinovirus strain sensitivity to HBB and D-HBB HCl; leaves open hypothesis-generating antiviral research in preclinical models.

Structured PICO

Population

Rhinovirus strains representative of the 55 numbered serotypes and one subtype tested in HeLa and WI-38 cell culture tubes

Intervention

2-(α-hydroxybenzyl)-benzimidazole (HBB) at 223 and 447 μM, and D-(-)-2-(α-hydroxybenzyl)-benzimidazole HCl (D-HBB HCl) at 77, 115, 192, 383, and 574 μM

Outcome

Viral inhibitionsurrogate

Rhinoviruses as a group show a wide range of sensitivity to HBB and D-HBB HCl, with most types sharing some degree of sensitivity to D-HBB HCl.

Limitations

Difficulty in separating virus-specific from toxic actions of the compounds at higher concentrations

Cite This Study

Jack M. Gwaltney (1968) studied this question.

synapsesocial.com/papers/6a87d03802f504243ce96457 https://doi.org/10.3181/00379727-129-33393

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The Spectrum of Rhinovirus Inhibition by 2-( -Hydroxybenzyl)-benzimidazole and D-(-) -2- ( -Hydroxybenzyl)-benzimidazole HC1

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The Spectrum of Rhinovirus Inhibition by 2-( -Hydroxybenzyl)-benzimidazole and D-(-) -2- ( -Hydroxybenzyl)-benzimidazole HC1

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider