Key result
3-substituted triazinoindoles, particularly SK&F 30097, inhibited rhinovirus growth in cell cultures with a minimum inhibitory capacity of 21 to 32 μM without altering cell morphology.
Population
Rhinovirus strains in WI-38 and HeLa cell cultures
Design
Preclinical
Authors
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May identify antiviral leads; leaves open translation from cell culture to in vivo or clinical efficacy.
3-substituted triazinoindoles, particularly SK&F 30097, demonstrate in vitro inhibitory activity against rhinovirus strains without altering host cell morphology.
Jack M. Gwaltney (1970) studied Rhinovirus infection (in vitro). 3-substituted triazinoindoles (SK&F 28938 and SK&F 30097) was evaluated on Minimum inhibitory capacity for rhinoviruses. 3-substituted triazinoindoles, particularly SK&F 30097, inhibited rhinovirus growth in cell cultures with a minimum inhibitory capacity of 21 to 32 μM without altering cell morphology.
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