November 1, 1972Experimental Biology and Medicine

The Antiviral Effect of a Triazinoindole (SK&F 40491) in Rhinovirus Infected Gibbons

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Why the study?

Does intranasal SK&F 40491 reduce viral shedding and antibody response in gibbons infected with human rhinovirus type 2?

Population

Gibbons infected with human rhinovirus type 2

Comparison

SK&F 40491 administered intranasally in a… vs Placebo

Design

Preclinical

Authors

CPC. A. PintoChildren's Hospital of Philadelphia HBH. P. BahnsenUpsher-Smith Laboratories (United Kingdom)LRLouis J. RavinUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

May support antiviral testing in rhinovirus models; hypothesis-generating and leaves open human translation.

Structured PICO

Does intranasal SK&F 40491 reduce viral shedding and antibody response in gibbons infected with human rhinovirus type 2?

Population

Gibbons infected with human rhinovirus type 2

Intervention

SK&F 40491 (a triazinoindole) administered intranasally in a multidose regimen as a 0.02% solution or a 2.5% suspension

Comparator

Placebo

Outcome

Quantity of virus recovered from the nose, and serum and nasal antibody responsesurrogate

Intranasal administration of SK&F 40491 demonstrates antiviral activity against human rhinovirus type 2 in a gibbon model.

Cite This Study

Pinto et al. (1972) studied this question.

synapsesocial.com/papers/6a87cf833f31f6b699bb61b6 https://doi.org/10.3181/00379727-141-36800

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The Antiviral Effect of a Triazinoindole (SK&F 40491) in Rhinovirus Infected Gibbons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Antiviral Effect of a Triazinoindole (SK&F 40491) in Rhinovirus Infected Gibbons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider