Key result
SK&F 40491, a triazinoindole, demonstrated broad-spectrum and selective in vitro antiviral activity, particularly against picornaviruses, at concentrations well below cytotoxic levels.
Population
in vitro models (viruses, notably picornaviruses)
Design
Preclinical
Authors
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No current clinical role; leaves open further preclinical development of triazinoindoles against picornaviruses.
SK&F 40491 demonstrates selective broad-spectrum antiviral activity in vitro, particularly against picornaviruses.
Haff et al. (1972) studied this question. SK&F 40491, a triazinoindole, demonstrated broad-spectrum and selective in vitro antiviral activity, particularly against picornaviruses, at concentrations well below cytotoxic levels.
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