What question did this study set out to answer?

To evaluate the sex-specific impact of hypovitaminosis D and its interplay with diabetes mellitus on coronary artery disease severity.

November 12, 2024Journal of Clinical MedicineOpen Access

The Co-Existence of Hypovitaminosis D and Diabetes Mellitus Triples the Incidence of Severe Coronary Artery Disease in Women

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Authors

AAAneta AleksovaAzienda Sanitaria Universitaria Integrata di Trieste MJMilijana JanjusevicUniversity of Trieste BPBeatrice PaniUniversity of Trieste

Discussion

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Implication

Cohort study reveals that vitamin D deficiency combined with diabetes triples severe coronary artery disease risk in women, highlighting synergistic cardiovascular dangers.

Key Points

To evaluate the sex-specific impact of hypovitaminosis D and its interplay with diabetes mellitus on coronary artery disease severity.
Enrolled 1,484 consecutive patients presenting with acute myocardial infarction.
Defined hypovitaminosis D as 25-hydroxyvitamin D ≤ 20 ng/mL and severe coronary artery disease as left main or three-vessel stenosis > 50%.
Women had significantly lower median vitamin D concentrations than men (15.7 ng/mL vs. 17.9 ng/mL, p = 0.01).
Severe coronary artery disease occurred more frequently in women with hypovitaminosis D than in those without (33% vs. 19%, p < 0.01; adjusted OR: 1.85, p = 0.01), an association not observed in men.
Women presenting with both hypovitaminosis D and diabetes mellitus had more than three times the odds of severe coronary artery disease compared to those with neither condition (OR: 3.56, p = 0.02).

Cite This Study

Aleksova et al. (2024) studied this question.

synapsesocial.com/papers/6a87d0674f54442d18262ff5 https://doi.org/10.3390/jcm13226792

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November 12, 2024Journal of Clinical MedicineOpen Access

The Co-Existence of Hypovitaminosis D and Diabetes Mellitus Triples the Incidence of Severe Coronary Artery Disease in Women

View Full Paper

Ask AI

Bookmark

Authors

AAAneta AleksovaAzienda Sanitaria Universitaria Integrata di Trieste MJMilijana JanjusevicUniversity of Trieste BPBeatrice PaniUniversity of Trieste

Discussion

Member takes

Implication

Cohort study reveals that vitamin D deficiency combined with diabetes triples severe coronary artery disease risk in women, highlighting synergistic cardiovascular dangers.

Key Points

To evaluate the sex-specific impact of hypovitaminosis D and its interplay with diabetes mellitus on coronary artery disease severity.
Enrolled 1,484 consecutive patients presenting with acute myocardial infarction.
Defined hypovitaminosis D as 25-hydroxyvitamin D ≤ 20 ng/mL and severe coronary artery disease as left main or three-vessel stenosis > 50%.
Women had significantly lower median vitamin D concentrations than men (15.7 ng/mL vs. 17.9 ng/mL, p = 0.01).
Severe coronary artery disease occurred more frequently in women with hypovitaminosis D than in those without (33% vs. 19%, p < 0.01; adjusted OR: 1.85, p = 0.01), an association not observed in men.
Women presenting with both hypovitaminosis D and diabetes mellitus had more than three times the odds of severe coronary artery disease compared to those with neither condition (OR: 3.56, p = 0.02).

Cite This Study

Aleksova et al. (2024) studied this question.

synapsesocial.com/papers/6a87d0674f54442d18262ff5 https://doi.org/10.3390/jcm13226792

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