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November 15, 2001Journal of VirologyOpen Access

Poliovirus 5′-Terminal Cloverleaf RNA Is Required in cis for VPg Uridylylation and the Initiation of Negative-Strand RNA Synthesis

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Population

Chimeric poliovirus RNAs in cell-free reaction mixtures

Design

Preclinical

Authors

TLTraci R. LyonsUniversity of Colorado Anschutz Medical CampusKMKenneth E. MurrayFlorida International UniversityARAllan W. RobertsUniversity of Colorado Health

Discussion

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Implication

May inform poliovirus antiviral design; leaves open clinical translation pending human validation.

Structured PICO

P
Population
Chimeric poliovirus RNAs in cell-free reaction mixtures
I
Intervention
Replacement of the 5' nontranslated region (NTR) of poliovirus with the 5' NTR of hepatitis C virus
O
Outcome
VPg uridylylation and initiation of negative-strand RNA synthesis

The 5'-terminal cloverleaf of poliovirus RNA is essential in cis for initiating negative-strand RNA synthesis.

Cite This Study

Lyons et al. (2001) studied this question.

synapsesocial.com/papers/6a87d2703f31f6b699bb63b7https://doi.org/10.1128/jvi.75.22.10696-10708.2001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection1998 · 360 citations
  2. 2Identification of an RNA Hairpin in Poliovirus RNA That Serves as the Primary Template in the In Vitro Uridylylation of VPg2000 · 293 citations
  3. 3Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C1997 · 167 citations
  4. 4Requirements for Assembly of Poliovirus Replication Complexes and Negative-Strand RNA Synthesis2001 · 77 citations
  5. 5Replication of poliovirus RNA and subgenomic RNA transcripts in transfected cells1992 · 73 citations