The entire structural domain I of the 5' non-translated genomic region in coxsackievirus B3 RNA is not required for productive replication.
CVB domain I deletion permits replication in animal models; extends viral RNA mapping but leaves open relevance to human myocarditis.
Domain I is a cloverleaf-like secondary structure at the 5' termini of all enterovirus genomes, comprising part of a cis-acting replication element essential for efficient enteroviral replication. 5' genomic terminal deletions up to as much as 55% of domain I can occur without lethality following coxsackie B virus infections. We report here that the entire CVB structural domain I can be deleted without lethality.
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Jaramillo et al. (2016) studied this question.
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