Differential Targeting of Nuclear Pore Complex Proteins in Poliovirus-Infected Cells
Population
Poliovirus-infected cells and whole-cell lysates from uninfected cells
Comparison
Poliovirus infection and addition of purified… vs Uninfected cells
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Nup98 cleavage may aid poliovirus immune evasion; leaves open therapeutic targeting pending human studies.
Structured PICO
P
Population
Poliovirus-infected cells and whole-cell lysates from uninfected cells
I
Intervention
Poliovirus infection and addition of purified rhinovirus type 2 2A(pro)
C
Comparator
Uninfected cells
O
Outcome
Cleavage of nuclear pore complex (NPC) proteins (Nup98, Nup153, Nup62)surrogate
Poliovirus rapidly targets the interferon-inducible NPC protein Nup98 for cleavage early in infection, likely as a mechanism to overcome host defense mechanisms.
Cite This Study
Park et al. (2007) studied this question.