“Colomycin”—Laboratory and Clinical Investigations

24-hour period. The tubular reabsorption of solute-free water for the six days of therapy was calculated to be 315 ml./24 hours. Sodium excretion decreased from an average control value of 78 mEq/24 hours to 11 mEq on the sixth day of diazoxide therapy. The administration of diazoxide had no apparent effect on endogenous creatinine clearance, indicating that the fluid retention was not due to a reduced glomerular filtration rate. Blood-pressure fell from an average of 156/105 mm. Hg during the control period to 128/88 mm. Hg by the third day of therapy.