Doxorubicin-induced cytotoxicity in fibroblasts is primarily mediated by ROCK1-dependent actin cytoskeleton remodeling rather than oxidative stress.
No takes yet. Share an insight, caveat, or question.
ROCK1 may mediate doxorubicin cytotoxicity beyond oxidative stress in fibroblasts; leaves open whether targeting it improves cardiac outcomes in patients.
Wei et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: