Why the study?
Does the AT2 receptor antagonist PD 123319 alter forearm blood flow or vascular resistance responses to AngII in normal volunteers?
Does the AT2 receptor antagonist PD 123319 alter forearm blood flow or vascular resistance responses to AngII in normal volunteers?
AT2 receptors do not appear to play a significant role in regulating forearm blood flow or vascular resistance in normal human volunteers.
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AT2 blockade leaves AngII forearm responses unchanged in healthy volunteers; confirms negligible AT2 role in normal human peripheral vascular regulation.
It has been hypothesized that the expression of angiotensin (Ang) II type 2 (AT(2)) receptors may become important in vascular disease; however, the functional existence of AT(2) receptors in normal adult humans remains to be established. 2. Vascular responses to AngII after the administration of the specific AT(2) receptor antagonist PD 123319 were determined in the forearm circulation of normal volunteers. 3. PD 123319 (8 microg/min) did not alter basal forearm blood flow, or forearm blood flow or forearm vascular resistance responses to AngII. 4. These results suggest that AT(2) receptors do not play a significant role in the regulation of forearm blood flow or forearm vascular resistance of normal volunteers, but do not preclude a role for AT(2) receptors in other vascular beds or in patients with cardiovascular disease.
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Phoon et al. (2001) studied this question.
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