November 1, 1994AJP Heart and Circulatory Physiology
Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism
Why the study?
Does epinephrine alter myocardial energy substrate preference and ATP production in isolated working rat hearts?
Population
Isolated working rat hearts perfused with 11 mM glucose, 0.4 mM palmitate, and 100 muU/ml insulin at an…
Comparison
1 microM epinephrine vs Baseline/control without epinephrine
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May enhance ATP via glucose preference under catecholamine stress in models; leaves open translation to human HF or ischemia.
Structured PICO
Does epinephrine alter myocardial energy substrate preference and ATP production in isolated working rat hearts?
P
Population
Isolated working rat hearts perfused with 11 mM glucose, 0.4 mM palmitate, and 100 muU/ml insulin at an 11.5-mmHg left atrial preload and a 60-mmHg aortic afterload
I
Intervention
1 microM epinephrine
C
Comparator
Baseline/control without epinephrine
O
Outcome
Glucose and fatty acid metabolism (glycolysis, glucose oxidation, fatty acid oxidation, and ATP production)surrogate
Epinephrine increases myocardial ATP production required for contractile function through a preferential increase in glucose utilization rather than fatty acid oxidation.
Cite This Study
Collins-Nakai et al. (1994) studied this question.