Why the study?
Does blunting the hypertrophic response improve survival and preserve cardiac function in animal models of pressure-overload and myocardial infarction?
Population
Animal models of pressure-overload and myocardial infarction
Design
Review
Authors
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Challenges adaptive view of hypertrophy in animals; leaves open human translation and needs clinical trials.
Does blunting the hypertrophic response improve survival and preserve cardiac function in animal models of pressure-overload and myocardial infarction?
Recent animal experiments challenge the classical view of left ventricular hypertrophy as an adaptive response, showing that blunting hypertrophy preserves cardiac function and improves survival.
Meijs et al. (2006) studied this question.
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