Genomewide Association Studies in Cardiovascular Disease—An Update 2011
Design
Review
Authors
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Implication
Adds to CVD genetic loci catalog; leaves open most heritability and clinical translation.
Key Points
- To review recent advances from genomewide association studies in discovering susceptibility genes and genetic mechanisms underlying major cardiovascular diseases.
- Conducted a structured literature review using PubMed search terms including 'genome wide association studies,' 'genetic polymorphism,' 'genetic risk factors,' 'association study,' 'risk score,' and 'transcriptome.'
- Identified multiple novel genetic loci associated with myocardial infarction, hypertension, heart failure, stroke, and hyperlipidemia, frequently pointing to unsuspected genes or alterations in gene expression.
- Demonstrated that identified variants explain only a modest proportion of disease heritability, leaving substantial missing heritability that requires whole-genome sequencing to resolve.
Cite This Study
Zeller et al. (2011) studied this question.