Why the study?
Does insulin-induced hypoglycemia affect plasma renin activity in humans?
Does insulin-induced hypoglycemia affect plasma renin activity in humans?
Insulin-induced hypoglycemia increases plasma renin activity via sympathetic reflex stimulation mediated by cyclic AMP, independent of adrenal or pituitary function.
Hypoglycemia may confound plasma renin activity assessment; leaves open its role in counter-regulatory responses.
The effect of insulin-induced hypoglycemia upon plasma renin activity (PRA) was assessed in 4 normal volunteers, 4 adrenalectomized patients and 10 patients with various pituitary hormone deficiences. Significant increases in PRA were observed in all three groups. The PRA responses to hypoglcemia could be blocked by propranolol, and appeared to be potentiated by theophyline. It is concluded that sympathetic reflex stimulation, not adrenal-dependent and not pituitary-dependent, is the major mechanism for this phenomenon in man and that this adrenergic effect may be mediated by cyclic AMP.
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Lowder et al. (1975) studied this question.
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