Why the study?
Does apixaban resolve left atrial thrombus in a patient with breast cancer?
Does apixaban resolve left atrial thrombus in a patient with breast cancer?
Answers are grounded in this paper and cite their sources.
May support apixaban as warfarin alternative for left atrial thrombus in breast cancer; hypothesis-generating, should not change practice.
BACKGROUND: Left atrial thrombi have traditionally been treated with heparin and warfarin, and many physicians have limited experience with direct oral anticoagulants such as apixaban. Furthermore, the efficacy of apixaban for the treatment of left atrial thrombi has not been established. We experienced a case of left atrial thrombus formation before breast cancer surgery, which was resolved by apixaban. CASE PRESENTATION: Computed tomography for a 74-year-old Japanese woman with breast cancer incidentally revealed a left atrial mass with a root before the breast surgery. The mass was surgically removed and determined to be a thrombus. Before the breast surgery, transthoracic echocardiography was performed again, and the left atrial thrombus had recurred within only 14 days. It resolved after administration of apixaban. CONCLUSIONS: A left atrial thrombus might recur within a very short time. Apixaban might be an alternative to warfarin in patients with breast cancer and left atrial thrombus.
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Sugawara et al. (2016) studied this question.
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