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G protein-coupled transduction is a recurrent theme in cell function. It enables diverse extracellular first messengers to activate intracellular second-messenger responses that produce diverse biologic effects. G proteins, which stand out as uniform and unifying components in the midst of great diversity, may be subject to dysfunctions that have wide-ranging pathophysiologic importance.
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Allen M. Spiegel (1988) studied this question.
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