What question did this study set out to answer?

To evaluate the clinical spectrum of faciobrachial dystonic seizures and assess whether immunotherapy improves seizure control and prevents cognitive impairment compared with antiepileptic drugs.

September 6, 2013Brain

Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype

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Authors

SISarosh R. IraniJacksonville College CSCharlotte J. StaggUniversity of Oxford JSJonathan M. SchottGerman Center for Neurodegenerative Diseases

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Implication

Prospective study demonstrates immunotherapy rapidly controls seizures and prevents cognitive decline in faciobrachial dystonic seizures, highlighting the need for early immune treatment.

Key Points

To evaluate the clinical spectrum of faciobrachial dystonic seizures and assess whether immunotherapy improves seizure control and prevents cognitive impairment compared with antiepileptic drugs.
Prospective study of 10 consecutive cases identified over 20 months with serial assessments of seizure frequencies, cognitive function, and antibody levels.
Evaluated responses to antiepileptic drugs versus immunotherapy (corticosteroids) and performed post-recovery cross-sectional volumetric brain MRI compared to 13 healthy controls.
Immunotherapy controlled faciobrachial dystonic seizures significantly more effectively than antiepileptic drugs (P = 0.006), with corticosteroids halting seizures within one week in 3/9 and within two months in 6/9 drug-refractory cases.
All 8 patients receiving antiepileptic drugs alone or no treatment developed cognitive impairment compared to 0 of 2 treated with immunotherapy (P = 0.02), with time to recovery correlating with time to immunotherapy (r = 0.74; P = 0.03).
Post-recovery volumetric MRI showed significantly smaller brain volumes in cases (n = 8) than healthy controls (n = 13) (P < 0.001).

Cite This Study

Irani et al. (2013) studied this question.

synapsesocial.com/papers/6a87dea16841b83273ad3142 https://doi.org/10.1093/brain/awt212

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Implication

Prospective study demonstrates immunotherapy rapidly controls seizures and prevents cognitive decline in faciobrachial dystonic seizures, highlighting the need for early immune treatment.

Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype

Discussion

Member takes

Implication

Key Points

Cite This Study

Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype

Discussion

Member takes

Implication

Key Points

Cite This Study

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