Population
Freshly dispersed porcine coronary artery smooth muscle cells
Comparison
Cytoplasmic ATP, cytoplasmic Ca2+, voltage… vs Control conditions (absence of these agents)
Design
Preclinical
Authors
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May implicate ATP-sensitive K+ channels in ischemic coronary regulation; hypothesis-generating and leaves open human translation or therapeutic relevance.
Identifies a potassium channel in porcine coronary artery smooth muscle cells sensitive to ATP, calcium, and voltage, suggesting a potential role in regulating coronary blood flow during ischemia.
Silberberg et al. (1990) studied this question.
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